GENETIC ENCYCLOPEDIA
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gene: HMGN3

id9324
symbolHMGN3
organismHomo sapiens
full namehigh mobility group nucleosomal binding domain 3
summaryThe protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]
variant-disease

GRCh37/hg19 6q14.1(chr6:79848942-80086173)x3 AND not provided

GRCh37/hg19 6q14.1(chr6:78216253-82753743)x3 AND not provided

GRCh38/hg38 6q14.1(chr6:78661176-80245532)x1 AND See cases

GRCh37/hg19 6q13-14.2(chr6:73674612-84829774)x1 AND not provided

GRCh38/hg38 6q12-14.2(chr6:64549655-83426791)x1 AND See cases

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