GENETIC ENCYCLOPEDIA
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gene: LATS1

id9113
symbolLATS1
organismHomo sapiens
full namelarge tumor suppressor kinase 1
summaryThe protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
variant-disease

NM_004690.4(LATS1):c.2636G>A (p.Trp879Ter) AND Peritoneal mesothelioma

NM_004690.4(LATS1):c.2365G>C (p.Asp789His) AND Ependymoma

GRCh37/hg19 6q24.3-25.1(chr6:148690764-150494873)x1 AND See cases

GRCh37/hg19 6q24.2-25.1(chr6:144947731-150266155)x1 AND not provided

GRCh38/hg38 6q24.3-25.1(chr6:147580351-150227963)x3 AND See cases

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