GENETIC ENCYCLOPEDIA
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gene: RUNX3

id864
symbolRUNX3
organismHomo sapiens
full nameRUNX family transcription factor 3
summaryThis gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
variant-disease

GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 AND See cases

GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 AND multiple conditions

GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 AND not provided

GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 AND See cases

GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 AND not provided

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