gene: TRIM5

organismHomo sapiens
full nametripartite motif containing 5
summaryThe protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

GRCh37/hg19 11p15.4(chr11:5701837-5702305)x1 AND not provided

GRCh37/hg19 11p15.4(chr11:5701837-5702409)x0 AND not provided

NM_001003819.3:c.1058G>A AND Malignant tumor of prostate

GRCh37/hg19 11p15.4(chr11:5485210-5719251)x1 AND See cases

GRCh37/hg19 11p15.4(chr11:5610674-6032001)x3 AND not provided

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