GENETIC ENCYCLOPEDIA
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gene: TPH1

id7166
symbolTPH1
organismHomo sapiens
full nametryptophan hydroxylase 1
summaryThis gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]
variant-disease

GRCh37/hg19 11p15.1(chr11:17899742-18258290)x3 AND not specified

GRCh37/hg19 11p15.1(chr11:16820813-18103432)x3 AND See cases

GRCh37/hg19 11p15.1(chr11:16436272-18064677)x3 AND not provided

GRCh37/hg19 11p15.1(chr11:17527585-18606820)x1 AND not provided

GRCh37/hg19 11p15.1(chr11:16775884-18418719)x3 AND not provided

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