GENETIC ENCYCLOPEDIA
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gene: TPBG

id7162
symbolTPBG
organismHomo sapiens
full nametrophoblast glycoprotein
summaryThis gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
variant-disease

GRCh37/hg19 6q14.1-14.2(chr6:82987696-84007694)x1 AND not provided

Single allele AND Immunodeficiency 23

GRCh37/hg19 6q13-14.2(chr6:73674612-84829774)x1 AND not provided

GRCh37/hg19 6q14.1-16.1(chr6:81261418-97796269)x3 AND not provided

GRCh38/hg38 6q12-14.2(chr6:64549655-83426791)x1 AND See cases

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