GENETIC ENCYCLOPEDIA
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gene: MPO

id4353
symbolMPO
organismHomo sapiens
full namemyeloperoxidase
summaryMyeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
variant-disease

NM_000250.2(MPO):c.518A>G (p.Tyr173Cys) AND Myeloperoxidase deficiency

NM_000250.2(MPO):c.2031-2A>C AND Myeloperoxidase deficiency

MPO, -463G-A AND Lung cancer, protection against, in smokers

MPO, -463G-A AND Alzheimer disease, susceptibility to

NM_000250.2(MPO):c.2031-2A>C AND not provided

... 27 more


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