GENETIC ENCYCLOPEDIA
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gene: ME1

id4199
symbolME1
organismHomo sapiens
full namemalic enzyme 1
summaryThis gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
variant-disease

GRCh37/hg19 6q14.2(chr6:84029282-84124184)x1 AND See cases

GRCh37/hg19 6q14.2(chr6:84056520-84136451)x1 AND See cases

GRCh37/hg19 6q14.2(chr6:84064628-84117542)x1 AND not provided

GRCh37/hg19 6q14.1-14.2(chr6:83753213-84004063)x3 AND See cases

GRCh37/hg19 6q14.1-14.2(chr6:83788069-84228464)x3 AND See cases

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