GENETIC ENCYCLOPEDIA
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gene: INSC

id387755
symbolINSC
organismHomo sapiens
full nameINSC spindle orientation adaptor protein
summaryIn Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
variant-disease

GRCh38/hg38 11p15.2(chr11:14914381-15240180)x3 AND See cases

GRCh37/hg19 11p15.2(chr11:14924646-15279421)x3 AND See cases

GRCh38/hg38 11p15.2(chr11:14924804-15253488)x3 AND See cases

GRCh38/hg38 11p15.2(chr11:14684722-15210307)x3 AND See cases

GRCh38/hg38 11p15.2(chr11:14619894-15179026)x3 AND See cases

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