GENETIC ENCYCLOPEDIA
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gene: DHDH

id27294
symbolDHDH
organismHomo sapiens
full namedihydrodiol dehydrogenase
summaryThis gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
variant-disease

NM_014475.3(DHDH):c.611A>T (p.His204Leu) AND Malignant tumor of prostate

GRCh37/hg19 19q13.33(chr19:49447713-49470073)x1 AND not provided

GRCh37/hg19 19q13.33(chr19:49389934-49477474)x1 AND not provided

GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 AND See cases

GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 AND See cases

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