gene: SESN1

organismHomo sapiens
full namesestrin 1
summaryThis gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GRCh38/hg38 6q21(chr6:107445281-110547907)x1 AND See cases

GRCh37/hg19 6q16.1-21(chr6:97384446-110247755)x1 AND See cases

GRCh38/hg38 6q21-22.1(chr6:107370141-115827482)x1 AND See cases

GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1 AND See cases

GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1 AND See cases

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