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gene: RPL13A

id23521
symbolRPL13A
organismHomo sapiens
full nameribosomal protein L13a
summaryRibosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
variant-disease

GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 AND See cases

GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 AND See cases

GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 AND See cases

GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) AND See cases

GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 AND not provided

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