GENETIC ENCYCLOPEDIA
ABOUT US    

   

gene: CLDN7

id1366
symbolCLDN7
organismHomo sapiens
full nameclaudin 7
summaryThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
variant-disease

GRCh37/hg19 17p13.1(chr17:7121580-7186623)x3 AND Ductal breast carcinoma

GRCh37/hg19 17p13.1(chr17:7120452-7165252)x3 AND Ductal breast carcinoma

GRCh37/hg19 17p13.1(chr17:7013365-7265208)x1 AND not provided

GRCh38/hg38 17p13.1(chr17:6891357-7264234)x3 AND See cases

Single allele AND multiple conditions

... 19 more


Partner site take online screenshot of website on site-shot.com.